The crash occurred in the westbound lanes between Route 512 and Schoenersville Road around 3:30 p.m., LehighValleyLive reports citing PSP Trooper Nathan Branosky.
Two of the vehicles went up in flames and another hit the center median, sending one victim to the hospital and injuring several others, Branosky said.
The road was reopened shortly before 5 p.m. following the crash, Branosky said.
Click here to follow Daily Voice Bristol and receive free news updates.